Gabapentin and pregabalin are examples of which class?

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Multiple Choice

Gabapentin and pregabalin are examples of which class?

Gabapentin and pregabalin belong to the alpha-2-delta calcium channel ligand class. They bind to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, which reduces calcium influx at presynaptic terminals and lowers the release of excitatory neurotransmitters like glutamate, substance P, and norepinephrine. This dampens neuronal excitability and gives anticonvulsant and neuropathic pain–modulating effects. Although they’re structurally related to GABA, they do not act on GABA receptors, and they are not dopamine agonists or serotonin reuptake inhibitors.

Gabapentin and pregabalin belong to the alpha-2-delta calcium channel ligand class. They bind to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, which reduces calcium influx at presynaptic terminals and lowers the release of excitatory neurotransmitters like glutamate, substance P, and norepinephrine. This dampens neuronal excitability and gives anticonvulsant and neuropathic pain–modulating effects. Although they’re structurally related to GABA, they do not act on GABA receptors, and they are not dopamine agonists or serotonin reuptake inhibitors.

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