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Multiple Choice

In NREM sleep, the CO2 response is:

In non-REM sleep the respiratory control system keeps responding to CO2 much like it does when awake. The central chemoreceptors in the brainstem detect CO2-derived changes in pH in the CSF, and the ventilatory drive rises in response. Although overall breathing is slower and the baseline ventilation is reduced during NREM, the sensitivity to CO2—the way ventilation increases as CO2 rises—remains largely preserved, so the CO2 response is similar to wakefulness. This preservation helps maintain CO2 homeostasis during NREM, whereas in REM sleep the CO2 responsiveness tends to be reduced.

In non-REM sleep the respiratory control system keeps responding to CO2 much like it does when awake. The central chemoreceptors in the brainstem detect CO2-derived changes in pH in the CSF, and the ventilatory drive rises in response. Although overall breathing is slower and the baseline ventilation is reduced during NREM, the sensitivity to CO2—the way ventilation increases as CO2 rises—remains largely preserved, so the CO2 response is similar to wakefulness. This preservation helps maintain CO2 homeostasis during NREM, whereas in REM sleep the CO2 responsiveness tends to be reduced.